Spatial transcriptomic-metabolic features of tumor foci and tumor capsule in microvascular invasion with hepatocellular carcinoma: A spatial multi-omics study - PubMed
3 days ago
- #Hepatocellular carcinoma
- #Metabolic reprogramming
- #Spatial transcriptomics
- Identified a malignant cell subtype (STMN1+HMGN2+GPC3+) enriched in MVI+ HCC tumors with enhanced proliferation and poor prognosis.
- Found suppressed glycerolipid metabolism in the identified malignant cell population, indicating metabolic reprogramming.
- Observed downregulation of iCAFs-related genes in MVI+ tumor capsules and distal location of iCAFs from the tumor boundary.
- Linked taurine in the tumor capsule to iCAF activity suppression, promoting HCC proliferation and migration.
- Validated findings through clinical cohorts (79 patients), TCGA-LIHC (n=299), and an independent dataset (n=62).
- Concluded that MVI+ HCC involves a proliferative, metabolically reprogrammed cell subtype and taurine-mediated iCAF modulation.