Soluble α2δ-1, altered in disease CSF, modulates network homeostasis and rescues deficits in a neuropsychiatric mouse model - PubMed
5 hours ago
- #therapeutic potential
- #neuropsychiatric disorders
- #network homeostasis
- Soluble α2δ-1, found in human cerebrospinal fluid (CSF), modulates network homeostasis.
- Levels of soluble α2δ-1 are reduced in schizophrenia (SZ) patients.
- Synthetic ectodomain of Alpha2Delta-1 (SEAD1) enhances parvalbumin-positive (PV+) interneuron function and restores excitation-inhibition (E/I) balance.
- A single SEAD1 injection in a SZ mouse model reversed synaptic and behavioral deficits, including memory and social impairments.
- Soluble synaptic ectodomains represent a new class of extracellular signaling molecules with therapeutic potential for neuropsychiatric disorders.
- Researchers have filed a provisional patent related to these findings for a CSF-derived therapy for psychiatric disorders.