Stress granule phase separation in stress-responsive cytosolic extract-in-oil droplets - PubMed
5 hours ago
- #microfluidics
- #biomolecular condensates
- #stress granules
- Stress granules (SGs) are biomolecular condensates that form in mammalian cells during stress, with dysregulation linked to age-related diseases.
- An emulsion-based microfluidics method using 'cytosolic extracts-in-oil droplets' (CEODs) mimics the cytosolic environment for SG formation under physiological conditions.
- CEODs enabled the discovery of seven new SG components involved in signaling pathways, offering a cost-effective screening platform for future therapeutic studies.