PRMT5 inhibition impairs Fanconi Anemia pathway-mediated homologous recombination and enhances the antitumor efficacy of Temozolomide in glioblastoma - PubMed
5 hours ago
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- #PRMT5
- #glioblastoma
- PRMT5 inhibition enhances the cytotoxic effect of temozolomide in glioma stem-like cells.
- PRMT5 inhibition impairs the Fanconi anemia pathway-mediated homologous recombination repair, increasing DNA damage.
- Combination therapy of PRMT5 inhibitor and temozolomide reduces tumor growth and improves survival in mouse models.