Periventricular diffusivity at the ventricular-parenchymal interface across healthy controls, episodic migraine, and chronic migraine: a cross-sectional multimodal MRI study - PubMed
5 hours ago
- #Migraine
- #MRI Phenotype
- #Neurology
- Periventricular diffusivity (PVeD) is an indirect MRI marker at the ventricular-parenchymal interface.
- In this study, 289 adults were analyzed: 67 healthy controls, 162 episodic migraine (EM), and 60 chronic migraine (CM).
- Age- and sex-adjusted PVeD was significantly lower in CM compared to EM and healthy controls.
- Lower PVeD correlated with higher headache frequency and greater patient burden (HIT-6, MIDAS scores).
- PVeD could serve as a potential MRI phenotype for future chronification-risk and treatment-response studies after validation.