Drugging cold-response networks for neuroprotection - PubMed
5 hours ago
- #neuroprotection
- #RNA-mechanisms
- #hypothermia-mimicry
- Therapeutic hypothermia is neuroprotective but difficult to initiate and sustain clinically.
- Pharmacological strategies aim to mimic 'cold' protection at normal body temperature.
- Recent advances include RNA mechanisms like temperature-gated splicing and RNA G-quadruplexes (rG4).
- The review focuses on RNA layer mechanisms, with upstream elements as context.
- A translational roadmap highlights RBM3, splice-switching antisense oligonucleotides, and rG4 chemotypes.
- Key considerations include pharmacodynamic anchors, clinical windows, and safety for hypothermia mimetics.