Plasma p-tau217 Versus p-tau181 in Parkinson's Disease: Differential Associations with Alzheimer's Disease-Related Neurostructural Changes and Cognitive Function - PubMed
5 hours ago
- #Alzheimer's disease
- #Parkinson's disease
- #biomarkers
- Plasma p-tau217 and p-tau181 are biomarkers for Alzheimer's disease pathology, studied in Parkinson's disease patients.
- P-tau217 showed stronger associations than p-tau181 with AD-like neurostructural changes in PD.
- Higher levels of both biomarkers were found in PD patients with cognitive impairment and dementia compared to cognitively normal PD.
- P-tau217 correlated more strongly with multidomain cognitive deficits, disease severity, and reduced functional independence in PD.
- The study suggests plasma p-tau217 and p-tau181 can serve as scalable markers of AD-related processes in Parkinson's disease.