Noninvasive, Rapid, and Precise Identification of Esophageal Cancer via Salivary Extracellular Vesicle-Based Diagnosis - PubMed
6 hours ago
- #Salivary Extracellular Vesicles
- #Esophageal Cancer Diagnosis
- #Biomarker Discovery
- The Saliva Extracellular vesicle-based Early Diagnostic system (SEEDx) enables noninvasive, rapid, and precise identification of esophageal cancer via salivary EVs.
- The system integrates the EXODUS platform for EV isolation and TMT-based proteomics analysis, achieving high diagnostic accuracy with a 9-marker model (AUC of 0.996 for EC and 0.991 for early-stage EC).
- A cost-effective two-marker model (HDGF and CALR) was developed, demonstrating AUC values of 0.950 for EC and 0.935 for early-stage EC, validated in an independent cohort with AUCs of 0.873 and 0.854, respectively.
- This workflow extends EXODUS to salivary EVs, addressing previous limitations in isolation and identification for early cancer detection.