Decreased salivary ZG16B expression is associated with exocrine dysfunction in Sjögren disease - PubMed
6 hours ago
- #salivary biomarkers
- #ZG16B
- #Sjögren disease
- Decreased salivary ZG16B expression is linked to exocrine dysfunction in Sjögren disease (SjD).
- Proteomic and metabolomic analysis of saliva from SjD patients showed significant changes in protein and metabolite levels.
- ZG16B was significantly reduced in SjD patients and correlated with tear and salivary flow rates.
- The study suggests ZG16B as a promising noninvasive biomarker for SjD.
- Findings highlight epithelial injury, immune activation, and compromised energy metabolism in SjD salivary glands.