Safety concerns associated with various types of statins: a disproportionality analysis of the FAERS database - PubMed
6 hours ago
- #pharmacovigilance
- #statins
- #adverse drug reactions
- Comparative ADR profiles across statins (Atorvastatin, Simvastatin, Rosuvastatin, Pravastatin, Lovastatin, Fluvastatin, Pitavastatin) analyzed using FAERS data (2004Q1-2024Q2) with ROR and PRR.
- Common ADRs across all statins include elevated Blood Creatine Phosphokinase, Chromaturia, and elevated Hepatic Enzymes; elevated Blood Urea shared except in Pitavastatin.
- Specific ADRs identified: Atorvastatin linked to hearing loss, Rosuvastatin to skeletal-related ADRs, and Pravastatin to premature labor, attributed to pharmacokinetic and structural differences.
- Study highlights underrecognized safety signals and distinct reporting patterns, suggesting need for further clinical investigations into statin-specific risks.