Single-cell genomics highlight MYC-associated metabolic activation and altered cell interactions in T-prolymphocytic leukemia progression - PubMed
2 days ago
- #MYC
- #single-cell genomics
- #T-PLL
- T-prolymphocytic leukemia (T-PLL) often progresses rapidly, but 15-25% of cases start indolently before advancing.
- Single-cell RNA sequencing of 28 samples, including 11 indolent/active pairs, reveals patient-specific and common gene expression changes.
- Active T-PLL shows upregulation of MYC-target genes, linked to enhanced energy metabolism and autonomy from energetic restrictions.
- Downregulation of T-cell-receptor signaling genes and reduced interactions with non-leukemic cells indicate escape from regulatory survival signals.
- This study provides insights into tumor evolution mechanisms in T-PLL, suggesting potential targetable lesions.