Recent Advances in Vitiligo Treatment - PubMed
8 hours ago
- #precision medicine
- #JAK inhibitors
- #vitiligo treatment
- JAK inhibitors are established as first-line therapy for vitiligo by blocking the IFN-γ/JAK-STAT signaling pathway, achieving significant repigmentation.
- Novel biologics like IL-15 inhibitors show promise by selectively eliminating pathogenic CD8+ T cells to suppress immune-mediated damage at its source.
- Combination therapies, such as 308 nm excimer laser with JAK inhibitors or platelet-rich plasma (PRP), increase repigmentation rates in acral lesions to 56.1%.
- For stable vitiligo, ReCell technology combined with narrowband UVB (NB-UVB) and miniature punch grafting optimize surgical treatment outcomes.
- Drug repurposing and antioxidant strategies, along with vitamin D adjunct therapy, expand the clinical arsenal for vitiligo treatment.
- The treatment landscape is shifting towards precision immune modulation, with innovations in combined phototherapy and cellular therapy enhancing repigmentation efficiency.