TBXA2R activates ERMs to drive motility, invasion, and metastatic colonization of TNBC cells - PubMed
5 hours ago
- #ERM activation
- #cancer metastasis
- #TBXA2R
- TBXA2R activates ERMs to enhance motility, invasion, and metastatic colonization in triple-negative breast cancer (TNBC) cells.
- ERM activation by TBXA2R involves Gαq/11, Gα12/13, Rho GTPases, and kinases SLK and LOK.
- TBXA2R-driven metastasis depends on ERM function, revealing a novel signaling axis in cancer progression.
- This discovery offers potential for targeted therapies against cancer metastasis.