Exploring the Lung-Liver Axis in Pulmonary Arterial Hypertension - PubMed
3 days ago
- #Pulmonary Arterial Hypertension
- #Lung-Liver Axis
- #Liver Fibrosis
- Liver plays a role in PAH pathogenesis via inflammatory injury to pulmonary endothelium.
- PAH patients with MELD-Na ≥ 12 have higher pulmonary vascular resistance and reduced exercise capacity.
- IL-6 is identified as a key hub in inflammatory pathways linking liver dysfunction to PAH.
- Liver fibrosis trends are observed in PAH patients and models, supporting a lung-liver axis.
- Subclinical liver dysfunction clusters are associated with worse clinical outcomes in PAH.