Deletion of Mfn2 in endothelial cells triggers a mitohormetic response that improves systemic metabolism and healthspan in mice - PubMed
4 days ago
- #aging
- #metabolism
- #mitochondria
- Deletion of Mfn2 in endothelial cells (ECs) triggers a mitohormetic response, improving systemic metabolism and healthspan in mice.
- Mfn2 deficiency in ECs enhances antioxidant defenses, mitochondrial fitness, and lipid oxidation, leading to better metabolic outcomes.
- ECs secrete GDF15 via a FOXO1-dependent axis, observed both in vitro and in vivo under stress conditions.
- Mfn2i��EC mice showed elevated GDF15 levels, and GDF15 neutralization partly reversed metabolic benefits.
- Mfn2i��EC mice were protected against diet-induced obesity and age-related decline, highlighting vascular mitohormesis as a novel health-promoting mechanism.