Associations of triglyceride-glucose-related composite obesity indices with cardiovascular diseases and mortality: a systematic review and meta-analysis - PubMed
5 hours ago
- #meta-analysis
- #TyG index
- #cardiovascular disease
- The systematic review and meta-analysis examines the associations between TyG-based composite obesity indices and cardiovascular diseases and mortality.
- Key indices studied include TyG-BMI, TyG-WC, TyG-WHtR, TyG-ABSI, and TyG-BRI.
- Per 1-SD increase, CVD risk rose by 17% for TyG-BMI, 20% for TyG-WC, and 19% for TyG-WHtR, while TyG-BRI was not significantly associated.
- For stroke, risk increased by 18% for TyG-BMI, 18% for TyG-WC, 37% for TyG-WHtR, and 17% for TyG-BRI.
- CAD risk increased by 17% for TyG-BMI, 18% for TyG-WC, and 22% for TyG-WHtR per 1-SD.
- Cardiovascular mortality rose by 22% for TyG-BMI, 24% for TyG-WC, 32% for TyG-WHtR, and 31% for TyG-ABSI; all-cause mortality increased by 5% for TyG-BMI, 18% for TyG-WC, 21% for TyG-WHtR, and 23% for TyG-ABSI.
- Categorical analyses showed highest vs lowest quantile associations with higher risk for most indices, except TyG-BMI was not significant for all-cause mortality.
- TyG-WHtR and TyG-WC had slightly greater risk increments than TyG-BMI for some outcomes.
- Dose-response analyses revealed non-linear associations for TyG-BMI, TyG-WC, and TyG-WHtR with CVD and cardiovascular mortality, while TyG-BMI showed a U-shaped association with all-cause mortality.
- TyG-based composite obesity indices may supplement traditional risk assessment for risk stratification and early identification in primary prevention.