The Landscape of Prostate Tumour Methylation - PubMed
4 hours ago
- #Prostate Cancer
- #Epigenomics
- #DNA Methylation
- Prostate cancer exhibits significant clinical and molecular heterogeneity, with epigenomic aspects less understood than genomic ones.
- A compendium of 3,001 multi-ancestry prostate methylomes was created, covering normal tissue to poly-metastatic disease, with 884 samples having multi-omic DNA/RNA data.
- Four epigenomic subtypes were identified that risk-stratify patients and reflect distinct evolutionary trajectories.
- Extensive regulatory interplay exists between DNA copy number and methylation, with transcriptional consequences varying across genes and disease stages.
- Epigenetic dysregulation signatures for 15 clinico-molecular features were defined, enabling predictive models for each, including features that predict patient outcome and synergize with clinical prognostic factors.
- The study reveals a complex interplay between tumour genetics and epigenetics that modifies gene-expression programs and clinical presentation, partly through epigenetic aging modulation.