MicroRNA profiles in plasma-derived extracellular vesicles across the human lifespan - PubMed
8 days ago
- #aging
- #extracellular vesicles
- #miRNA
- Extracellular vesicles (EVs) are analyzed from a healthy aging cohort to study changes across the human lifespan.
- Older individuals show shifts in EV immunophenotype, indicating immunosenescence, and distinct miRNA signatures.
- Key miRNAs like miR-206, miR-143-3p, miR-122-5p, and miR-20b-3p are linked to muscle, metabolic, and vascular function.
- miR-6529-5p, associated with neuroprotection, is elevated in aging.
- EV miRNAs and particle counts correlate with biological aging markers such as GDF-15, visceral fat, and muscle quality.
- The study suggests EVs as potential minimally invasive biomarkers for biological aging and functional decline.