Association Between Ketogenic Diet and Overactive Bladder: The Mediating Roles of Dietary Inflammatory Index and Weight-Adjusted Waist Index - PubMed
6 hours ago
- #ketogenic-diet
- #inflammation
- #overactive-bladder
- Overactive bladder (OAB) is linked to urinary urgency, frequency, and nocturia, affecting quality of life and healthcare burden.
- Ketogenic diet patterns are associated with weight reduction, decreased inflammation, and improved metabolic profiles, but their connection to OAB was unclear.
- Study analyzed data from 23,763 NHANES participants (2009-2018), including 4,991 with OAB, using dietary recalls and validated indices (DKR, DII, WWI).
- Higher Dietary Inflammatory Index (DII) increased OAB odds by 11%, while higher Dietary Ketogenic Ratio (DKR) reduced OAB odds by 43%.
- Participants in the highest DKR quartile had significantly lower OAB prevalence compared to the lowest quartile.
- Mediation analysis showed DII and WWI accounted for 8.29% and 6.57% of the DKR-OAB association, respectively.
- Findings suggest ketogenic diets may lower OAB risk partially by reducing inflammation and central adiposity, warranting further research.