Tau conformation, distribution and PET imaging correlations in progressive supranuclear palsy - PubMed
6 hours ago
- #PET Imaging
- #Tauopathy
- #Neuropathology
- Progressive supranuclear palsy (PSP) is a primary tauopathy characterized by aggregated pathological tau.
- Recent cryo-electron microscopy advances allow classification of tauopathies at near-atomic resolution, revealing disease-specific tau filament conformations.
- Tau microstructure differences affect intracellular localization, intercellular propagation, and spatial distribution of tau pathology.
- Microstructural variations influence microscopic binding profiles and macroscopic imaging signatures of tau PET tracers.
- The review delineates PSP's tau architecture, cellular and spatial distributions compared to other tauopathies.
- It critically discusses the clinical utility and limitations of tau PET imaging in PSP.
- The goal is to bridge neuropathological insights with in vivo PET findings.