Integrative genomic analysis of 21 orofacial diseases identifies shared genetic architecture with systemic diseases - PubMed
3 hours ago
- #Genomic Analysis
- #Systemic Health
- #Orofacial Diseases
- The study conducted an integrative genomic analysis of 21 orofacial diseases using data from the UK Biobank, identifying 48 novel loci and 160 putative causal genes.
- A synonymous variant in the ALDH1A2 gene linked to periodontitis was found to reduce translational efficiency, impacting retinoic acid synthesis and leading to an imbalanced immune response.
- Mendelian randomization analysis revealed a causal effect of Sjögren's syndrome on lung cancer and stroke, while dental caries and periodontitis showed shared genetic pathways with systemic diseases like nicotine-related pathways without clear causality.