Calsyntenin-3 suppresses inflammation via inhibition of TLR N-glycosylation and membrane localization - PubMed
5 hours ago
- #N-glycosylation
- #TLR
- #inflammation
- Calsyntenin-3 (CLSTN3) suppresses inflammation by inhibiting TLR N-glycosylation and membrane localization.
- CLSTN3 binds to DDOST, impairing OST complex assembly, reducing TLR4 N-glycosylation and membrane translocation.
- CLSTN3 also inhibits membrane translocation and activation of other TLRs (TLR3, TLR7, TLR9).
- Reduced CLSTN3 expression correlates with increased cytokine levels in inflammatory diseases like sepsis.
- CLSTN3 presents a potential therapeutic target for inflammatory diseases by controlling TLR glycosylation.