Akkermansia Muciniphila Alleviates Severe Acute Pancreatitis via Amuc1409-Ube2k-Foxp3 Axis in Regulatory T Cells - PubMed
4 hours ago
- #Severe Acute Pancreatitis
- #Regulatory T Cells
- #Akkermansia muciniphila
- Akkermansia muciniphila abundance is reduced in acute pancreatitis patients and inversely correlates with inflammation severity.
- Amuc_1409 protein from A. muciniphila reduces SAP inflammation by increasing Tregs and IL-10 expression.
- Mechanism involves Amuc_1409 binding to Ube2k to inhibit Foxp3 ubiquitination, enhancing Treg differentiation and anti-inflammatory effects.