The multifunctional RNA helicase DDX39A drives glioblastoma progression by modulating WISP1 alternative splicing that induces an immunosuppressive macrophage polarization - PubMed
6 hours ago
- #immunosuppression
- #glioblastoma
- #RNA helicase
- DDX39A, a multifunctional RNA helicase, is significantly upregulated in glioblastoma (GB) and promotes tumor progression.
- DDX39A modulates WISP1 alternative splicing, stabilizing WISP1 pre-mRNA and activating the AKT signaling pathway.
- WISP1, secreted by tumor cells, induces immunosuppressive polarization of tumor-associated macrophages (TAMs).
- Reduction of DDX39A expression in GB leads to decreased tumor growth and invasion.
- Fluphenazine hydrochloride inhibits DDX39A, suppressing GB growth, invasion, and macrophage immunosuppressive function.
- DDX39A is a potential target for glioma-targeted therapy.