Plasma proteomics reveals divergent sex-specific senescence and bone biology signatures across neurodegenerative diseases - PubMed
5 hours ago
- #neurodegenerative-diseases
- #plasma-proteomics
- #sex-differences
- The study explores the connection between neurodegenerative diseases (Alzheimer’s disease, Lewy body dementia, and Parkinson’s disease) and systemic changes in bone health and cellular senescence.
- Proteomic analysis of 408 participants showed sex-specific differences in circulating bone- and senescence-related proteins tied to these diseases.
- Pathway analysis identified common mitochondrial and metabolic dysfunction across these conditions, with disease-specific disruptions like vesicle trafficking in Alzheimer’s and inflammatory-senescence pathways in Lewy body dementia.
- Key candidate proteins were associated with neurodegeneration markers, especially pTau181, and highlighted sex-divergent patterns in inflammation and bone-related pathways.