Amphotericin B promotes respiratory viral entry by enhancing late endosomal maturation and fusion via glucocerebrosidase-mediated ceramide remodeling - PubMed
3 days ago
- #antifungal therapy
- #Amphotericin B
- #viral entry
- Amphotericin B (AmB) enhances the entry of influenza A virus and SARS-CoV-2 by promoting late endosomal maturation and fusion.
- AmB binds to and activates glucocerebrosidase, leading to ceramide accumulation and RAB7 upregulation in late endosomes.
- Animal models show AmB treatment increases viral infection severity, including higher viral loads and tissue damage.
- Clinical data from 1,072 patients indicates AmB use is associated with a higher incidence of subsequent viral infections compared to other antifungals.
- AmB is identified as an independent risk factor for viral infections in patients with invasive pulmonary aspergillosis.
- The study suggests glucocerebrosidase as a potential target for developing new antiviral strategies.