Somatic genomics as a discovery engine for biomedicine - PubMed
5 days ago
- #biomedicine
- #somatic mutations
- #drug discovery
- Somatic mutations, occurring after conception, are widespread in healthy tissues and traditionally seen as signs of aging or pre-cancer.
- Emerging research shows somatic mutations can drive or protect against disease, offering new therapeutic strategies.
- Somatic mutations provide a rich substrate for discovering disease-related mutant genes, such as those in hematopoietic or liver cells.
- Somatic genetics complements germline genetics, impacting biomedicine and drug development significantly.
- The review explores factors shaping somatic mosaicism and highlights mutations causing or protecting from disease.
- Somatic mutations are becoming crucial for disease genetics, drug target identification, and clinical translation.