An anti-adhesive compound modulating the production of Staphylococcus aureus cell wall-anchored proteins - PubMed
5 hours ago
- #geranylgeranoic acid
- #anti-adhesive
- #Staphylococcus aureus
- Geranylgeranoic acid (GGA) is a natural compound with dual activity against methicillin-resistant Staphylococcus aureus (MRSA).
- At high concentrations, GGA is microbicidal; at lower doses, it inhibits MRSA adhesion to proteins like keratin and fibronectin.
- GGA shows efficacy against multidrug-resistant S. aureus isolates and in mouse models of skin and soft tissue infections.
- Its anti-adhesive effect works by modulating the production of cell wall-anchored proteins, partly via inhibition of the SaeRS system.
- The findings highlight GGA's potential as a therapeutic agent against MRSA, offering a new decolonization strategy.