Autoantibodies neutralizing type I IFNs in 40% of patients with WNV encephalitis in seven new cohorts - PubMed
6 hours ago
- #WNV encephalitis
- #autoantibodies
- #type I IFNs
- Autoantibodies neutralizing type I IFNs found in 40% of WNV encephalitis patients across seven new cohorts.
- Prevalence of autoantibodies is highest in encephalitis patients (40%) and very low in asymptomatic or mild infections.
- Odds ratios for WNV encephalitis in individuals with autoantibodies range from ~20 to >2,000 compared to the general population.
- Preexisting autoantibodies neutralizing type I IFNs are causal for WNV encephalitis in about 40% of patients.
- Study includes cohorts from Europe, the Middle East, and America.