Accelerated intermittent theta burst stimulation targeting personalized fronto-parietal control network improves core symptoms of autism spectrum disorder: a double-blind, randomized controlled trial

6 hours ago

Accelerated intermittent theta burst stimulation (iTBS) targeting the personalized fronto-parietal network (FPN) was tested in a double-blind, randomized controlled trial for autism spectrum disorder (ASD).
The study included 67 participants aged 6-30 years with severe cognitive or adaptive impairments, comparing active iTBS to sham stimulation over 12 weeks.
Active iTBS resulted in a significantly higher response rate (55% vs. 29%) and greater symptom improvement compared to sham, with mild side effects like local pain in only 5% of the active group.
In the profound autism subgroup, active iTBS led to language improvement alongside core symptom alleviation, suggesting it as a safe and effective intervention for severe ASD.

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