Phospholipid Glutathione Peroxidase Overexpression Mitigates Cancer Cachexia by Protecting Muscle Mass and Lowering Inflammation - PubMed
5 hours ago
- #muscle wasting
- #GPx4
- #cancer cachexia
- Cancer cachexia affects ~80% of cancer patients and is a leading cause of death in 22%-30% of cases.
- Lack of effective therapies for muscle loss and dysfunction in cancer cachexia is a major challenge.
- Reactive oxygen species (ROS) and lipid peroxidation may contribute to cancer cachexia, with markers like 4-HNE and MDA elevated in tumor-bearing mice.
- Phospholipid hydroperoxide glutathione peroxidase (GPx4) reduces lipid hydroperoxides and was hypothesized to mitigate cancer cachexia.
- GPx4 overexpression in tumor-bearing mice protected muscle mass and mitochondrial respiration, reducing inflammation markers like IL-6.
- GPx4 overexpression did not improve muscle force generation but prevented the rise in inflammatory gene expression.
- Oxylipins generated by 12/15-Lox were elevated in tumor-bearing mice but unaffected by GPx4 overexpression.
- Future studies will explore mechanisms behind GPx4's protective effects in cancer cachexia.