Skin-mimetic bilayer hydrogel enhances spatiotemporal coordination of neuro-immune-vascular interactions to accelerate diabetic wound healing - PubMed
3 days ago
- #Bilayer hydrogel
- #Neuro-immune-vascular interactions
- #Diabetic wound healing
- Developed a skin-mimetic bilayer hydrogel to enhance diabetic wound healing by coordinating neuro-immune-vascular interactions.
- The bilayer design includes a protective, conductive upper layer and a responsive lower layer for on-demand drug delivery.
- The lower hydrogel releases calcitonin gene-related peptide early to suppress M1 macrophages and promote M2 macrophages.
- The upper layer releases magnesium ions and works with electrical stimulation to boost angiogenesis via VEGF signaling.
- Transcriptomic analysis shows the hydrogel enriches pathways related to extracellular matrix organization and angiogenesis.
- Offers a practical strategy for staged, precise wound repair in diabetes and a framework for chronic tissue regeneration.