Enalaprilat reverses neutrophil polarization imbalance via targeting taurine-STING axis for treatment of diabetic wounds - PubMed
6 hours ago
- #Neutrophil Polarization
- #Microneedle Drug Delivery
- #Diabetic Wound Healing
- A microneedle patch (TMZE@A-MN) with enalaprilat (Ena) targets neutrophils to treat diabetic wounds by reversing their polarization from pro-inflammatory N1 to anti-inflammatory N2 states.
- Ena works by increasing taurine levels, suppressing STING signaling via the NF-κB and Smad3 pathways, which reduces inflammation, macrophage switching, and endothelial ferroptosis.
- The delivery system uses a polypeptide to specifically target neutrophil receptors, enhancing Ena's effectiveness, and includes a metal-organic framework (MnZn-MOF) that eliminates free radicals and fights antibiotic-resistant bacteria.
- In vivo tests on diabetic mouse and pig models show that TMZE@A-MN accelerates wound healing, highlighting its potential as a targeted therapy for diabetic wounds.