Harnessing lipid-driven immunometabolic pathways in omental metastases to enhance immunotherapy in patients with ovarian cancer - PubMed
4 hours ago
- #immunotherapy
- #ovarian cancer
- #lipid metabolism
- Immunotherapy with immune checkpoint blockade (ICB) shows limited clinical benefit in epithelial ovarian carcinoma (EOC).
- Lipid-laden macrophages in omental metastases play a key role in immune suppression and therapeutic resistance.
- Lipid uptake by tumor-associated macrophages (TAMs) induces oxidative stress-dependent signaling, leading to dysfunction.
- Pharmacological modulation via CCR5 inhibition (maraviroc) or CD36 blockade reprograms TAMs and restores T cell activity.
- Humanized mouse models show maraviroc induces immune activation in lipid-laden TAMs.
- The immunometabolic niche in omental metastases correlates with ICB responsiveness.
- Non-invasive radiomics and machine learning can assess omental involvement for patient stratification.