Pigs with CD163 Mutation Conferred PRRSV Resistance - PubMed
5 hours ago
- #Disease Resistance
- #CRISPR
- #PRRSV
- PRRS causes significant economic losses in pig farming globally.
- CRISPR/Cas9 was used to create CD163-/- Landrace pigs resistant to PRRSV.
- Edited pigs showed no viral replication or organ damage post-PRRSV challenge.
- Wild-type pigs had high viral loads and severe organ damage.
- CD163 is confirmed as an essential receptor for PRRSV infection.
- CD163-/- pigs present a genetic strategy for breeding PRRSV-resistant pigs.