Investigating the Mechanism of Rehmannia glutinosa-Ephedra sinica in heart failure with preserved ejection fraction by Network Pharmacology, Metabolomics and Experimental Validation - PubMed
6 hours ago
- #Ferroptosis
- #Cardiovascular Research
- #Herbal Medicine
- Study investigates Rehmannia glutinosa-Ephedra sinica (MD) for treating heart failure with preserved ejection fraction (HFpEF).
- MD improves metabolic disorders, cardiac remodeling, and diastolic dysfunction in HFpEF models.
- Mechanisms involve PI3K/AKT signaling and ferroptosis regulation via GPX4/ACSL4 pathways.
- In vitro studies show MD-containing serum attenuates palmitic acid-induced metabolic dysfunction and ferroptosis.
- Findings suggest MD's cardioprotective effects are linked to metabolic and ferroptosis modulation.