The genetics of obesity: aetiology, prevention and therapy - PubMed
5 hours ago
- #genetics
- #obesity
- #precision-medicine
- Obesity is a complex condition with a strong genetic basis, including monogenic, oligogenic, and polygenic contributions.
- Over 1 billion people worldwide have obesity, including 150 million children.
- More than 85 monogenic forms of obesity have been identified, often associated with neurodevelopmental and other phenotypes.
- Genome-wide association studies have identified over 1,000 loci linked to weight variation.
- Advances in genetics have led to innovative therapeutic strategies, such as melanocortin 4 receptor agonists.
- Genetic discoveries are enabling precision medicine approaches to tailor obesity treatments based on individual genetic backgrounds.
- Future strategies aim to enhance prevention and personalize patient care using genetic insights.