Cryo-EM structures of light chain fibrils from abdominal fat biopsies of multiple myeloma patients - PubMed
6 hours ago
- #cryo-EM
- #amyloid fibrils
- #multiple myeloma
- Cryo-EM structures of light chain (LC) fibrils from abdominal fat biopsies of multiple myeloma (MM) patients were determined.
- Three distinct LC fibril morphologies were identified, differing from those in systemic light chain amyloidosis (AL).
- Structural comparisons suggest distinct fibrillation mechanisms in MM compared to AL amyloidosis.
- Elevated protein concentration may drive LC aggregation in MM.
- Findings provide molecular insights into LC fibril formation in MM and support biological diagnosis using abdominal fat biopsies.