RGS2 Promotes Brain Metastasis of Cisplatin-resistant Non-small Cell Lung Cancer through Caspase-1/IL-1beta Signaling Pathway - PubMed
6 hours ago
- #Cisplatin resistance
- #Non-small cell lung cancer
- #Brain metastasis
- Cisplatin-resistant NSCLC cells show enhanced brain metastasis compared to parental cells.
- RGS2 is significantly upregulated in cisplatin-resistant and brain metastatic NSCLC cells.
- RGS2 knockdown reduces brain metastatic capacity of cisplatin-resistant NSCLC cells.
- RGS2 activates the caspase-1/IL-1beta signaling pathway, promoting tumor cell-endothelial adhesion and compromising BBB integrity.
- Targeting the RGS2/caspase-1/IL-1beta pathway may help prevent brain metastasis in chemotherapy-resistant NSCLC.
- RGS2 has potential as a biomarker for monitoring and predicting NSCLC brain metastasis.