Ginkgolic acid targets HSPA8 to trigger ferroptosis in hepatocellular carcinoma via chaperone-mediated autophagy-dependent GPX4 degradation - PubMed
8 hours ago
- #autophagy
- #HCC therapy
- #ferroptosis
- Ginkgolic acid (GAC), from Ginkgo biloba, inhibits hepatocellular carcinoma (HCC) cell viability by inducing ferroptosis.
- GAC directly targets HSPA8, enhancing its interaction with glutathione peroxidase 4 (GPX4).
- This interaction leads to CMA-dependent degradation of GPX4, reducing glutathione levels and causing lipid peroxidation.
- In vivo studies show GAC suppresses tumor growth in an orthotopic HCC model, increasing lipid peroxidation and GPX4 degradation.
- The findings suggest GAC-mediated ferroptosis as a potential therapeutic strategy against HCC, expanding applications for CMA-targeted therapies.