Biomineralized nanoemulsion delivers mRNA for potent cancer immunotherapy - PubMed
5 hours ago
- #nanoemulsion
- #mRNA vaccine
- #cancer immunotherapy
- Developed a PEG-free nanoemulsion (NE) for mRNA delivery, reducing hepatic accumulation issues common in lipid nanoparticles (LNPs).
- Used biomineralization to anchor Mn2+ onto human serum albumin (HSA), creating manganese-modified nanoemulsion (MnNE), which activates the STING pathway and reduces cytotoxicity.
- MnNE showed superior transfection efficiency in antigen-presenting cells compared to Moderna's LNP formulation after intramuscular injection.
- In studies using ovalbumin (OVA) as a model antigen, MnNE-mOVA induced strong humoral and cellular immune responses.
- In both prophylactic and therapeutic tumor models, MnNE-mOVA significantly suppressed tumor growth and improved survival compared to LNP-based vaccines.
- MnNE-mOVA effectively reversed the immunosuppressive tumor microenvironment, demonstrating potential as a safe and effective mRNA vaccine platform for cancer immunotherapy.