Single-Cell and Spatial Omics: Methods and Applications - PubMed
6 hours ago
- #single-cell omics
- #computational biology
- #spatial omics
- Single-cell and spatial omics enable high-resolution molecular profiling, revealing cellular heterogeneity and spatial organization in biomedical research.
- Advances include high-throughput, subcellular, and multiomics profiling, along with computational progress like generative AI and foundation models for multimodal data.
- Applications span human organ systems in health and disease, aiding biomarker discovery, therapeutic target identification, and precision medicine.
- Challenges remain in bridging rapid methodological advances with systematic application for deciphering human biology and pathology.
- This review synthesizes technological breakthroughs, computational methods, and applications to guide researchers and accelerate translational impact.