Crosstalk between protein lipidation and ubiquitination in tumor biology - PubMed
12 hours ago
- #Protein lipidation
- #Tumor biology
- #Ubiquitination
- Protein lipidation and ubiquitination are key post-translational modifications influencing protein function in tumor biology.
- Their crosstalk regulates cancer processes like immune evasion, tumor microenvironment remodeling, and metastasis.
- Lipidation can protect proteins from ubiquitin-mediated degradation or recruit deubiquitinases.
- Ubiquitination controls the turnover and activity of lipidation enzymes, forming a dynamic regulatory network.
- Therapeutic strategies targeting this axis include NMT and DHHC enzyme inhibitors, PROTACs, and DUB inhibitors.
- This crosstalk presents a potential dual-modification target for precision oncology.