Multi-omics profiling reveals cholic acid-mediated immunosuppression driven by peritumoral ductular reactions in hepatocellular carcinoma - PubMed
12 hours ago
- #Cholic acid
- #Immunosuppression
- #Hepatocellular carcinoma
- Multi-omics profiling reveals cholic acid-mediated immunosuppression in hepatocellular carcinoma (HCC).
- Peritumoral ductular reactions predict poor clinical outcomes and correlate with cirrhosis severity.
- Three distinct cholangiocyte subpopulations identified, with Small_duct_type_Cho promoting stromal remodeling.
- Cholic acid enrichment at tumor margins induces CD8+ T cell dysfunction via NR1H4-dependent PD1 upregulation.
- NR1H4 inhibition synergizes with anti-PD1 therapy, significantly suppressing tumor growth in murine models.
- Ductular reactions serve as both a prognostic biomarker and therapeutic target in HCC.