The Impact of Multidimensional Frailty on Adverse Outcomes in Older Adults: A Systematic Review and Meta-Analysis - PubMed
6 hours ago
- #adverse outcomes
- #older adults
- #frailty
- Multidimensional frailty in older adults is associated with increased risks of adverse outcomes including mortality, falls, and hospitalization.
- A systematic review and meta-analysis of 26 studies involving 11,186 older adults found that 20.5%-80% exhibited multidimensional frailty.
- Frailty was linked to higher mortality (HR = 1.61, 95% CI: 1.37-1.89), falls (OR = 2.45, 95% CI: 1.29-4.64), and hospitalization (OR = 1.80, 95% CI: 1.29-2.52).
- Small-study effects were detected for mortality, with the association weakening but remaining significant after adjustment (HR = 1.27, 95% CI: 1.02-1.59).
- The study underscores the importance of early screening and preventive measures for frailty in older adults.