Folic acid alleviates endothelial dysfunction caused by T2DM-induced ferroptosis by activating the SIRT6/NRF2/GPX4 signaling pathway - PubMed
5 hours ago
- #ferroptosis
- #endothelial dysfunction
- #folic acid
- Folic acid protects against endothelial dysfunction in T2DM by reducing ferroptosis.
- The protective mechanism involves activation of the SIRT6/NRF2/GPX4 signaling pathway.
- In diabetic mouse models and high-fat, high-glucose-treated endothelial cells, folic acid reduced oxidative stress, iron accumulation, and lipid peroxidation.
- A SIRT6 inhibitor reversed folic acid's protective effects in vitro, confirming the pathway's role.
- Folic acid is suggested as a potential therapeutic agent for T2DM-related vascular complications.