Treating age-related loss of muscle mass and function: Where should we be focusing? - PubMed
5 hours ago
- #muscle aging
- #sarcopenia
- #neuromuscular health
- Increased life expectancy highlights the importance of healthy aging, with a well-functioning neuromuscular system being key to quality of life and independence.
- Age-related muscle loss (sarcopenia) involves multiple mechanisms: neurodegeneration, impaired proteostasis, deficient regeneration, hormonal decline, chronic inflammation, and dysregulation of muscle-resident cells.
- Recent research has improved understanding of muscle aging, identifying cellular origins of molecular signals and opening new avenues for targeted interventions.
- Current treatments focus on anabolic and catabolic signaling within muscle fibers, but may be ineffective if other cell types (e.g., muscle stem cells, motor neurons) drive muscle wasting.
- Individual differences (activity, nutrition, sex, comorbidities, genetics) influence the mechanisms of muscle loss, suggesting a need for multifactorial solutions.
- Scientists are exploring diverse causal mechanisms to develop effective interventions for age-related muscle wasting.