Frog gut bacterium eliminates cancer tumors in mice with a single dose

3 days ago

Copy Link

A bacterium from Japanese tree frog intestines shows strong tumor-killing abilities when administered intravenously.
Researchers isolated 45 bacterial strains from amphibians and reptiles, narrowing down to nine with anti-tumor effects.
Ewingella americana from tree frogs demonstrated the strongest tumor-targeting and cytotoxic activity.
The bacterium works through a dual-action mechanism: direct tumor cell killing and immune system activation.
In mice with colorectal cancer, a single dose of E. americana completely eliminated tumors and provided long-lasting immunity.
E. americana thrives in low-oxygen tumor environments, multiplying rapidly without harming healthy tissues.
The treatment triggered an immune response, flooding tumors with neutrophils, T cells, and B cells.
The bacterium is tumor-specific, sensitive to antibiotics, and showed no long-term toxicity in mice.
Researchers plan to test E. americana in breast cancer, pancreatic cancer, and melanoma, alongside existing therapies.
The findings suggest microbiome-derived bacteria could lead to new, transformative cancer treatments.

Hasty Briefsbeta