Temporal Evolution of Brain Inflammation in the Bilateral Common Carotid Artery Stenosis Model of Chronic Cerebral Hypoperfusion - PubMed
6 hours ago
- #BCAS model
- #chronic cerebral hypoperfusion
- #neuroinflammation
- Chronic cerebral hypoperfusion contributes to vascular cognitive impairment and dementia by disrupting white matter integrity and promoting neuroinflammation.
- The bilateral common carotid artery stenosis (BCAS) model is a key experimental approach for studying chronic cerebral hypoperfusion, especially in aging contexts.
- The review focuses on the temporal progression and functional consequences of inflammatory responses in the BCAS model.
- Early neurovascular unit dysfunction involves endothelial cells, pericytes, and astrocytes, leading to blood-brain barrier compromise.
- Inflammatory mediators like IL-1β, TNF-α, and IL-6 amplify injury, while microglia transition from acute responders to chronic effectors of white matter damage.
- There is a need for more causal tests to validate the shift from adaptive responses to maladaptive, self-sustaining inflammation.
- Future research should focus on cell-specific and time-resolved approaches to identify therapeutic targets for mitigating hypoperfusion-driven cognitive decline.