Autoantigen-loaded Polymeric Microparticles associate with B cells and promote tolerogenic antigen presentation in a mouse model of experimental autoimmune encephalomyelitis - PubMed
4 hours ago
- #microparticle delivery
- #B cell therapy
- #autoimmune tolerance
- Researchers developed antigen-loaded acetalated dextran microparticles (AMP) that associate with B cells to promote tolerogenic antigen presentation.
- In a mouse model of multiple sclerosis (MS), therapy using myelin peptide-loaded AMPs associated with B cells (MOG-AMP-B) led to recovery by reducing CNS inflammation and increasing regulatory cells.
- The therapy preserved protective immunity against viral infections, offering a potential antigen-specific treatment for autoimmunity without compromising overall immune function.